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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20181026T100000
DTEND;TZID=Europe/Paris:20181026T113000
DTSTAMP:20181019T140413Z
CREATED:20181019T135708Z
LAST-MODIFIED:20181019T140413Z
UID:4862-1540548000-1540553400@www.is2m.uha.fr
SUMMARY:Mesoporous silica nanoparticles for intracellular target drug release
DESCRIPTION:Prof. Marcos A. Bizeto  \nHybrid Materials Laboratory Chemistry Department\, Federal University of São Paulo\, Brazil \nmabizeto@unifesp.br \nLysosomes are cellular organelles responsible for degrade captured extracellular matter and digest intracellular substances. These compartments became the target site of the treatment of some infections and of many inflammatory\, neurodegenerative and auto-immune diseases. These organelles have also an important influence on the effectiveness of gene therapy treatments applied to cancers and other genetic and acquired disorders. \nOur research group is involved in the developing of mesoporous silica nanocarriers for use in gene therapy as non-viral vectors for DNA transfection. These vectors must present three main features: (i) have the right size and surface charge for being efficiently captured by cells through endocytosis; (ii) have the capability of complexing DNA molecules and protect them from the enzymatic degradation in lysosomes; (iii) ensure a rapid escape from lysosomes and promote the DNA release in the citosol. The vectors prepared satisfied quite well the first two and the studies are now focused on elaborating different strategies of promoting the delivery of lysosomotropic factors to accelerate the escape from the lysosomes. Prototypes of pH responsive mechanisms were developed to allow the target drug release only in lysosomes and some of them will be presented in the seminar.
URL:https://www.is2m.uha.fr/event/mesoporous-silica-nanoparticles-for-intracellular-target-drug-release/
LOCATION:Amphithéâtre de l’IS2M\, 15 rue jean starcky\, Mulhouse\, Mulhouse\, 68057\, France
ATTACH;FMTTYPE=image/jpeg:https://www.is2m.uha.fr/wp-content/uploads/2018/10/m_bizeto.jpg
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DTSTART;TZID=Europe/Paris:20181026T143000
DTEND;TZID=Europe/Paris:20181026T160000
DTSTAMP:20181019T141326Z
CREATED:20181019T140830Z
LAST-MODIFIED:20181019T141326Z
UID:4866-1540564200-1540569600@www.is2m.uha.fr
SUMMARY:Nanoparticles supported on non-modified cellulose films
DESCRIPTION:Fernanda Ferraz Camilo\nUniversidade Federal de São Paulo – Brazil \nhttp://www.researcherid.com/rid/L-2591-2013 \nThe application of nanomaterials as a powder or dispersion has several limitations such as difficulty in solid-liquid separation and in reuse and aggregation in the medium. An alternative to overcome this problem is to anchor the nanoparticles in suitable matrices. Cellulose films\, obtained from renewable source\, is an interesting material for use as support for nanomaterials due to its low cost\, abundance\, biodegradability and non-toxicity. In this presentation\, we will show the production of conductive films based on a combination of cellulose film with silver nanoparticles and a conducting polymer\, polyaniline [1]. Also\, we will present the immobilization of other silver and manganese dioxide nanoparticles aiming the production of curatives with cicatrizing and bactericidal activities and catalysts for the degradation of indigo carmine\, respectively. \n***************************************************************** \n[1] R. da S. Oliveira\, M.A. Bizeto\, F.F. Camilo\, Production of self-supported conductive films based on cellulose\, polyaniline and silver nanoparticles\, Carbohydr. Polym. 199 (2018) 84–91. doi:10.1016/j.carbpol.2018.06.049.
URL:https://www.is2m.uha.fr/event/nanoparticles-supported-on-non-modified-cellulose-films/
LOCATION:Amphithéâtre de l’IS2M\, 15 rue jean starcky\, Mulhouse\, Mulhouse\, 68057\, France
ATTACH;FMTTYPE=image/jpeg:https://www.is2m.uha.fr/wp-content/uploads/2018/10/f_camilo.jpg
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