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DTSTART;TZID=Europe/Paris:20221125T110000
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DTSTAMP:20260501T150128
CREATED:20221121T090037Z
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UID:7997-1669374000-1669379400@www.is2m.uha.fr
SUMMARY:Using microstructured substrates to control cellular behavior: contact guidance of vascular endothelial cells on microgrooves
DESCRIPTION:Claire Leclech\, a colleague from Lahyx lab\, Ecole Polytechnique\, Paris\, will give a talk at our institute next Friday (11am\, November 25\, amphi Starcky).\nYou are all welcome to join ! Please find below the abstract of the talk.\nYou can have a look at her last paper here : https://www.nature.com/articles/s41467-022-30488-0\n\n\nAdherent cells in vivo often reside on extracellular matrices (ECMs) that possess a topographical organization at different scales. Various types of engineered microstructured substrates have been developed to study the impact of basal topographical cues on cell behavior in vitro. Amongst them\, microgrooves mimicking the anisotropic organization of the ECM have been shown to align and elongate different cell types. However\, how cells detect and respond to microgrooves remains unclear\, particularly for cellular monolayers. We are investigating these questions using vascular endothelial cells (ECs)\, which form a monolayer lining the inner surfaces of blood vessels\, as a model. \nIn the first part of this presentation\, I will focus on the collective migration of vascular endothelial cell monolayers on microgrooved substrates. We describe the emergence of a specific pattern of collective motion characterized by large antiparallel cell streams\, which can be predicted in the physical framework of active fluids. I will then address the cellular and subcellular mechanisms underlying the contact guidance response of vascular endothelial cells on the microgrooves. We have in particular highlighted distinct regimes and mechanisms of response to topography in single cells vs. monolayers. Finally\, I will present some preliminary results on the deformation of cell nuclei on microgrooved substrates. We have characterized the cellular mechanisms leading to nuclear deformations in the grooves and investigated the links between nuclear deformations and mechanics. We believe that microgrooves constitute a new\, simple and high-throughput system to study cell and nuclear mechanics in physiological and/or pathological settings.
URL:https://www.is2m.uha.fr/event/using-microstructured-substrates-to-control-cellular-behavior-contact-guidance-of-vascular-endothelial-cells-on-microgrooves/
LOCATION:Amphithéâtre de l’IS2M\, 15 rue jean starcky\, Mulhouse\, Mulhouse\, 68057\, France
ATTACH;FMTTYPE=image/png:https://www.is2m.uha.fr/wp-content/uploads/2022/11/seminaire-grooveorateur.png
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DTEND;TZID=Europe/Paris:20221125T150000
DTSTAMP:20260501T150128
CREATED:20221107T141230Z
LAST-MODIFIED:20221107T141230Z
UID:7979-1669384800-1669388400@www.is2m.uha.fr
SUMMARY:Détermination du travail réversible d’adhésion à partir de courbes de forces de mouillage
DESCRIPTION:L’Institut de Science des Matériaux de Mulhouse (IS2M) reprend son cycle de séminaires intitulés « Séminaires Didactiques ». \nLes séminaires didactiques de l’IS2M ont pour objectif d’être accessibles aussi bien à des auditeurs non spécialistes qu’à des auditeurs plus experts dans le domaine.  \nL’objectif est de permettre ainsi à tous les auditeurs de comprendre l’objet des recherches présentées.  \nCes séminaires didactiques seront programmés les derniers vendredis du mois et auront lieu en hybride dans l’amphithéâtre de l’IS2M et par visioconférence (https://uha.webex.com/meet/benedicte.lebeau). \nTous les étudiants en thèse de l’IS2M doivent y assister dans la mesure où ces séminaires très « didactiques » sont mis en place notamment pour eux afin de leur permettre d’acquérir des connaissances pluridisciplinaires. \n Le prochain séminaire didactique aura lieu le vendredi 25 novembre à 14h (voir annonce ci-jointe). \n The Mulhouse Materials Science Institute (IS2M) is resuming its cycle of seminars entitled “Didactic Seminars”. IS2M’s didactic seminars aim to be accessible to both non-specialist and more expert attendees in the field.  \nThe objective is to enable all listeners to understand the purpose of the research presented.  \nThese didactic seminars will be scheduled on the last Friday of the month and will take place in hybrid in the IS2M amphitheater and by videoconference (https://uha.webex.com/meet/benedicte.lebeau). \nAll IS2M PhD students must attend these « didactic seminars » which are designed notably for them to acquire multidisciplinary knowledge. \n The next didactic seminar will take place on Friday 25 November at 2 pm
URL:https://www.is2m.uha.fr/event/determination-du-travail-reversible-dadhesion-a-partir-de-courbes-de-forces-de-mouillage/
LOCATION:Amphithéâtre de l’IS2M\, 15 rue jean starcky\, Mulhouse\, Mulhouse\, 68057\, France
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